7 Questions to ask yourself before bed

Greeting the day after a full night’s sleep is wholly different from starting a day after a night of restless sleep. If you find yourself asking the question “why can’t I sleep?” check out some of the information below to help you find your answer.

Read on to find out about specific nutrition and healthy habits that may alleviate your sleep difficulties. These tips are all backed by research, and so low-risk that they can be used in tandem. We really want to help you get some high-quality rest because sleep is so integral to feeling your best.

1. Am I making enough melatonin?

Melatonin is a hormone that the pineal gland produces naturally during hours of darkness. Its job is to regulate the “body clock” that controls when you’re awake and when your body is ready for sleep. This clock typically follows a 24-hour cycle called the circadian rhythm. The rhythm affects how every cell, tissue, and organ works [1]. 

Natural melatonin production requires a diet rich in the amino acid tryptophan, which is a precursor for serotonin, the precursor for melatonin [2]. Supplementing with melatonin does not change circulating levels of serotonin, or affect mood, but low levels of serotonin could be a cause for poor melatonin production and consequential difficulty sleeping [3]. 

Naturally, sufficient levels of circulating melatonin should spike at night to help us fall and stay asleep, but as we age, we tend to produce less and less melatonin [4]. Melatonin is available as a stand-alone nutrient for supplementation and in a range of dosing options. Metabolic Maintenance® offers a 2 mg melatonin capsule designed to help you both fall and stay asleep. Melatonin is also a key ingredient in the R.E.M. Maintenance™ Natural Sleep Support supplement powder. 

2. How much magnesium did I get today?

Magnesium promotes deep, restorative sleep [5]. Magnesium-related sleep trouble is often associated with both restless sleep and frequent waking during the night. Luckily, for many people there is an easy fix to this problem: magnesium supplements lead to deeper, more restful sleep [6,7,8].

The mechanism of magnesium’s effects on sleep is related to its role as a regulator of the parasympathetic nervous system, which is the system responsible for promoting calm and relaxation [6]. It also helps to regulate melatonin [7] and GABA, the neurotransmitter responsible for quieting the nervous system [8]. 

Unfortunately, as we age, the digestive system becomes less efficient. We tend to absorb less magnesium from the diet in later years, even if the amount of magnesium in our food stays the same. Alcohol and metabolic issues can exacerbate this problem [9]. 

Metabolic Maintenance® offers supplemental magnesium in multiple forms. Magnesium citrate, magnesium bound to citric acid, is one of the most bioavailable options. “Bioavailable” means the gut can easily absorb it, and it enters circulation for use throughout the body. It does, however, have a natural, gentle laxative effect. If you already have bowel issues that make a gentle laxative sound uncomfortable, you could try magnesium glycinate (magnesium bound to glycine) instead. This option is less likely to affect your bowels and glycine may also add to the relaxation effect of magnesium. Magnesium is also in Metabolic Maintenance®’s R.E.M. Maintenance™, in formulas with calcium, potassium, and/or zinc, as well as in most multivitamin formulas.

3. Should I start trading sugar for glycine?

Glycine is an amino acid that has a very sweet flavor and dissolves quickly and easily in water-based liquids (chamomile tea, anyone?).

Glycine is a very versatile amino acid in terms of the roles it plays throughout the body. It easily crosses the blood-brain barrier, inducing a calming effect on the brain and helping you wind down to prepare for sleep. Glycine triggers a reduction in core body temperature through vasodilation, which is an important biological step in the onset of sleep [10]. It also helps to regulate adrenal hormones, boosting wakefulness during the day [11].

Glycine also works as a neurotransmitter with balancing effects on parts of the brain and central nervous system. It plays a positive role in cognition, mood, appetite and digestion, immune function, perception of physical comfort, as well as restful sleep [12]. Glycine also plays a role in the production of other biochemicals that influence these body functions, including serotonin. 

4. Does my diet contain enough serotonin precursors?

We mentioned above that the body requires the amino acid tryptophan as a building block for serotonin production. Unfortunately, some people don’t get enough of this amino acid from their diet alone. Even if you do, the body must convert dietary tryptophan to 5-hydroxytryptophan, a.k.a. 5-HTP, before it can function as a precursor for serotonin. 5-HTP is the direct precursor for the production of serotonin and is therefore also an indirect precursor for melatonin. 

Supplementary 5-HTP bypasses the light-triggering system that regulates the natural release of melatonin, and provides the substrate for an increase in both serotonin and melatonin release, regardless of light or time of day. 

Because 5-HTP increases serotonin, it has a calming, relaxing effect on brain chemistry, and may help to ease any bedtime worries. Studies have shown that 5-HTP supplementation can help patients fall asleep faster and sleep more deeply than a placebo [13]. 

Metabolic Maintenance® offers both L-tryptophan and 5-HTP as stand-alone supplements. 5-HTP is also an ingredient in R.E.M. Maintenance™. Please consult your doctor before taking these supplements if you are undergoing SSRI therapy, as both target serotonin activity. 

5. Could a cup of tea wind me down?

Chamomile tea is a relaxation drink people commonly enjoy before bed. But, there is in fact some science to support the calming power of chamomile. Chamomile tea is the dry flowers of the chamomile plant, a member of the daisy family [14]. These flowers are rich in terpenoids and flavonoids, including a specific antioxidant flavonoid called apigenin. Apigenin binds to benzodiazepine receptors in the brain; the same receptors bound by drugs like diazepam (Valium). Although its effects are much more subtle, the signal released by these receptors tends to decrease anxiety and bring on sleep [14]. 

There are also compounds in chamomile that bind GABA receptors, mimicking effects of the calming neurotransmitter, GABA [14]. You can also supplement with GABA directly.

6. Did I get enough sunlight this morning?

Bright light may seem counterintuitive since a dark bedroom is best for sleep, but phototherapy in the morning may actually help you sleep soundly later. Photo- or light therapy is the act of having a bright light near your face for a period of time, simulating natural sunshine. Often, sleep difficulties arise from a disruption to the circadian rhythm. Melatonin at night can help get your body clock back on track, but so can bright light first thing in the morning. 

The light actually triggers photoreceptors that communicate with the hypothalamus, the portion of the brain ruling over the circadian clock [15]. Light stimulates a number of signaling cascades, telling your brain to wake up. If your mornings are often dark and gloomy, that could be contributing to your groggy feelings or daytime sleepiness. 

Not just any light will do, however. Phototherapy lamps or “lightboxes” are not the same as sun lamps or reading lamps. They filter harmful UV rays (so you won’t catch a tan) and emit a specific amount of sun-mimicking light, measured in “lux”. Your doctor can recommend the right strength of lux for your sleep-regulating needs, but lamps generally range from 2000 to 10,000 lux. The light must reach your eyes to trigger photoreceptors, so having the lamp near your face is a must. 

7. Is “meditation” the answer to EVERY question these days? 

Before you roll your eyes, consider the science! The first evidence of an association between meditation and sleep was published in 1997 [16]. That study showed individuals who practiced Transcendental Meditation (TM)® slept deeper, with more time in restorative slow-wave sleep than non-meditating subjects, as measured by electroencephalograph (EEG) [16]. It also showed that the longer people practiced, the more restful their sleep became. 

Since then, a lot of studies have been aimed at uncovering the mechanisms behind this phenomenon. It doesn’t just apply to TM either. Similar results are seen in mindfulness practice (vipassana meditation) [17]. In terms of the mechanism, meditation has been shown to reduce levels of stress hormones, cortisol, and catecholamines, through regulation of the hypothalamo pituitary adrenal (HPA) axis [17]. 

Meditation techniques can even raise melatonin levels by increasing production in the pineal gland and slowing breakdown in the liver [17]. Additionally, the natural deterioration of sleep as we age appears to be slowed by meditation. In other words, when older people meditate regularly, their sleep patterns tend to resemble the sleep patterns of younger people [17]. 

If you need help getting started with meditation, there are many meditation apps for your computer or smartphone (Headspace, Calm, etc.) and many free options on YouTube. You might consider searching “sleep meditation”, specifically. Some guided meditations are practiced during the day even though they are aimed at improving your nighttime sleep. Others are meant to be listened to in bed to send you off to sleep at night. Keep trying different guides and practices until you find one you connect with.


  1. https://www.nhlbi.nih.gov/health-topics/sleep-deprivation-and-deficiency
  2. https://jcsm.aasm.org/doi/full/10.5664/jcsm.6462
  3. https://www.hindawi.com/journals/tswj/2012/640389/
  4. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-079X.1986.tb00760.x
  5. https://europepmc.org/article/med/8363978
  6. https://link.springer.com/article/10.1007/s15006-016-9054-7
  7. https://europepmc.org/article/med/12030424
  8. https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=eedfae3cf0c82f37ee0fbf544d93d5aa60e20997
  9. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/.
  10. https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=eedfae3cf0c82f37ee0fbf544d93d5aa60e20997
  11. https://www.frontiersin.org/articles/10.3389/fnins.2017.00567/full
  12. https://thesleepdoctor.com/2018/07/23/understanding-glycine/
  13. https://europepmc.org/article/med/10711131?utm_medium=27156&client=bot&client=bot&client=bot
  14. https://www.spandidos-publications.com/mmr/3/6/895
  15. https://www.sciencedirect.com/science/article/abs/pii/S1087079215001136
  16. https://academic.oup.com/sleep/article/20/2/102/2731605
  17. https://www.frontiersin.org/articles/10.3389/fneur.2012.00054/full