Based on demand, Metabolic Maintenance® is proudly unveiling a brand new stress-support product: a relaxation and sleep aid, called Ashwagandha Plus. One of the best adaptogen supplements on the market, Ashwagandha Plus is available NOW!

Take 20% off Ashwagandha Plus until the end of June 2023!

No coupon required. This product is one of the best adaptogen supplements in part because the blend contains Shoden® brand Ashwagandha extract. Shoden® provides the most potent dose of active withanolides available on the market. 

Is this the right ashwagandha product for you?

If you already take a daily multivitamin, and you considering a complementary herbal calming aid, Ashwagandha Plus may be the right choice. 

Ashwagandha Plus

Ashwagandha is one of the most popular dietary supplements on the market in the US right now [1], but has a long history of use in Ayurvedic medicine as a “Rasayana”, or rejuvenator herb. Rasayana herbs rejuvenate the body and promote the health of all the tissues by eliciting a complex network of changes throughout the body [1]. One of many benefits backed by modern science, however, is helping the body respond to stress and anxiety. Regular supplementation with ashwagandha can actually reduce the activity of the HPA axis in response to stressors [2,3]

Aside from its benefits to stress and anxiety, ashwagandha can support healthier glucose (sugar) and triglyceride (fats) levels in the circulation, promote focus and memory, stimulate female sexual function and male fertility, maximize the effects of exercise, balance immune response, and promote healthy inflammatory response with anti-arthritic benefits [4,5]. 

Ashwagandha does not elicit one specific pharmacological mechanism. The processes it catalyzes in the body are holistic and complex. Adaptogens, like ashwagandha, reduce stress-induced damage and exhibit stimulating effects, but they are also innocuous, do not interfere with any bodily functions, and do not cause any negative effects or withdrawal symptoms [2].

Shoden® Ashwagandha Extract

A recent review summarizes about 140 specialized compounds isolated from ashwagandha [2]. Half of the compounds on this list are a complex group of steroidal lactones known as withanolides. 

Root and leaf extracts of ashwagandha, including the withanolides, have been shown to promote anti-stress and anti-anxiety effects in both human and animal studies [5]. Shoden® ashwagandha extract in Ashwagandha Plus has been standardized to 35% withanolides, making it the most potent ashwagandha extract on the market. Studies show that Shoden® ashwagandha extract is more bioavailable at lower doses than other products on the market, and so is effective at a lower dose level [6].

Ashwagandha Plus goes further than most ashwagandha supplements in another way. It also provides relaxation and stress-recovery support through L-theanine and magnesium bisglycinate.

Suntheanine® L-Theanine

L-Theanine is an amino acid that comes from green tea. It’s the calming, soothing chemical that balances tea’s caffeine (and the reason you’re less likely to get shaky after tea vs coffee). Whereas ashwagandha’s anti-stress benefits take regular supplementation to build up, L-theanine’s effects are immediate [7].

L-Theanine is structurally similar to glutamine and glutamate, and has been proven to cross the blood-brain barrier [7]. In the brain, L-theanine exhibits its effects through the modulation of glutamine, GABA, glycine, and dopamine [7]. Together, these neurotransmitters create a feeling of calm wellbeing in the body and mind. 

Magnesium Bisglycinate

Magnesium is the second most abundant cation found in intercellular fluid, and yet commonly lacking in the Western diet and quickly depleted in stress states [8]. One of hundreds of roles magnesium plays in the body is its regulation of stress hormones, norepinephrine and cortisol. It also participates in the relaxation of muscles throughout the body.

The magnesium in this formula is chelated with two molecules of glycine, another calming amino acid. Magnesium bisglycinate is significantly more absorbable in the intestines than other forms, and may be better for rebalancing magnesium levels than other types of supplementary magnesium [8].

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  1. Speers, Alex B., et al. “Effects of withania somnifera (ashwagandha) on stress and the stress-related neuropsychiatric disorders anxiety, depression, and insomnia.” Current Neuropharmacology 19.9 (2021): 1468.
  2. Salve, Jaysing, et al. “Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study.” Cureus 11.12 (2019).
  3. Lopresti, Adrian L., et al. “An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.” Medicine 98.37 (2019).
  4. Silva, Lauren. “7 Science-Backed Health Benefits Of Ashwagandha”. Forbes Health. Feb. 1, 2023.
  5. Bhosale, Shreya Dhanaji, R. Galib, and P. K. Prajapati. “Can Ashwagandha Leaf be Replace with its Root in Therapeutics? A Review through Published Literature.” Pharmacognosy Research 15.1 (2022).
  6. Deshpande, Abhijit, et al. “A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.” Sleep Medicine 72 (2020): 28-36.
  7. Wang, Liwen, et al. “How does the tea L-theanine buffer stress and anxiety.” Food Science and Human Wellness 11.3 (2022): 467-475
  8. Trapani, Gabriele. “How to choose among the many forms of magnesium on the market?.” (2021).